Skip to main content
Premium Trial:

Request an Annual Quote

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

In the journal eBioMedicine, University College London researchers propose plasma proteome profiling as a potential strategy for finding individuals at risk of developing long Covid infections. Using a nested case-control approach, the team collected blood samples over time from 156 healthcare workers at hospitals in London, comparing targeted plasma proteome features in 54 SARS-CoV-2-infected, non-hospitalized individuals and 102 SARS-CoV-2-uninfected individuals over time. Based on data spanning 91 targeted plasma proteins, the authors describe proteome shifts that lasted up to six weeks in infected individuals, including changes in the levels of lipid, atherosclerosis, cholesterol metabolism, and other pathways. In addition, they note, the analyses uncovered a proteomic signature present at the time of infection that appeared to show promise for predicting "post-acute sequelae of SARS-CoV-2," commonly known as long Covid, a year after the initial infection. "We show that signature biomarkers at the time of seroconversion for SARS-CoV-2 associates with the persistence of symptoms at 12 months," they report, noting that an iron-sulfur cluster biogenesis protein known as HSCB or HSC20 was the most predictive biomarker detected so far.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.