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Link Between Mosaic Loss of Y Chromosome, Heart Failure in Men

A study appearing in this week's Science reveals new details about how hematopoietic mosaic loss of Y chromosome (mLOY), a condition in which a fraction of hematopoietic cells lose the Y chromosome, contributes to an increased risk of mortality and age-related diseases in men. In the report, a group led by University of Virginia School of Medicine scientists present mouse model data supporting a causal link between hematopoietic mLOY and age-dependent cardiac dysfunction and heart failure in men. Specifically, they show that Y chromosome-deficient cardiac macrophages over-activate a profibrotic signaling network, leading to cardiac fibroblast proliferation and activation, excessive matrix production, and diminished heart function. Meanwhile, treatment with an antibody that neutralizes TGFb1, which is known to promote fibroblast proliferation, ameliorated cardiac dysfunction in mLOY mice. "In view of recent efforts to treat heart failure, idiopathic pulmonary fibrosis, and some cancers with antifibrotic approaches, men with mLOY could represent a patient subpopulation that exhibits a superior response to this class of therapeutic agents," the researchers write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.