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KRAS Mutations Retrospectively Detected in Circulating Tumor DNA Across Cancer Types

Investigators at the University of Texas MD Anderson Cancer Center, the Oregon Health and Science University, and Guardant Health describe KRAS-G12C mutations in circulating tumor DNA from individuals assessed by Guardant360 liquid biopsy testing. As they report in JCO Precision Oncology, the researchers analyzed data for 80,911 patients tested from July 2014 to late June 2019, uncovering KRAS-G12C mutations in more than 7 percent of non-small cell lung cancers and across 3.7 percent of all tumors tested. "[O]ur study demonstrates the feasibility of using ctDNA to identify KRAS-G12C mutations across solid tumors, with the highest detection rate in lung cancer as previously reported in the literature," the team writes, noting that it "found very high positive predictive value between tissue and liquid biopsies performed within [six] months of each other."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.