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Korean Team Presents ClinPharmSeq Clinical Pharmacogenomics Panel

In PLOS One, researchers from Macrogen, the Asian Genome Center, and the Seoul National University Bundang Hospital outline a targeted sequencing panel centered on dozens of genes implicated in pharmacogenetic (PGx) phenotypes — an approach aimed at "balance between low cost, high throughput, and deep coverage to overcome some of the challenges related to accurate detection of complex PGx polymorphism[s] including [structural variants]." The team applied its 59-gene ClinPharmSeq panel to 64 Coriell samples, collected from ancestrally diverse individuals, unearthing pharmacogenomics-related alleles that lined up with those identified using whole-genome sequencing or other approaches. "Altogether, these results demonstrate that the ClinPharmSeq platform offers a feasible path for broad implementation of PGx testing and optimization of individual drug treatments," the authors write.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.