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Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

Researchers at the Shanghai Jiaotong University, St. Jude Children's Research Hospital, and other centers describe genetic variants linked to Hodgkin lymphoma risk in children — including risk variants with ties to adult forms of the disease — for a paper appearing in JAMA Network Open. With array-based genotyping or whole-genome sequencing profiles for 1,286 individuals with childhood Hodgkin lymphoma, almost 6,200 individuals diagnosed with non-Hodgkin lymphoma forms of pediatric cancer, and 369 cancer-free controls, the team used a genetic association study to track down three human leukocyte antigen (HLA) SNPs linked to Hodgkin lymphoma risk, along with risk variants falling outside the HLA region. "Although the genetic etiology of [Hodgkin lymphoma] has been investigated, studies among patients with childhood-onset [Hodgkin lymphoma] are lacking," the authors explain, reporting that the risk variants identified "implicate multiple biological processes, including germinal center dysfunction, disrupted T-cell function, and nuclear factors-kappa-B activation, in [Hodgkin lymphoma] pathogenesis across age groups."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.