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Head and Neck Cancer Progression Features Found With Single-Cell Transcriptomics

For a paper appearing in Nature Communications, Ajou University investigators track head and neck squamous cell carcinoma (HNSCC) progression through single-cell RNA sequencing analyses on cells from normal tissue samples, samples representing a precancerous condition called leukoplakia, the primary tumor, and metastatic HNSCC samples found in the lymph node. The team's analysis of scRNA-seq profiles for more than 54,200 individual cells from 23 HNSCC patients pointed to the presence of carcinoma in situ cells in the precancerous lesions that appear to be missed by conventional pathology, for example, while flagging malignant or immune cell expression features coinciding with progression and poorer outcomes. "We demonstrate the stepwise alterations in cell composition during HNSCC progression, identifying cell clusters for malignant, stromal, and immune cells," the authors report, adding that the new findings "reveal the cell-cell interactions between tumor cells and their microenvironment, providing key mechanistic and clinical insights into HNSCCs."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.