Skip to main content
Premium Trial:

Request an Annual Quote

Gut Microbiome Differences Uncovered in Severe Versus Moderate COVID-19

The gut microbiomes of patients with severe COVID-19 differ from those of patients with a more moderate disease course, a new study has found. A team at Harvard Medical School analyzed the metagenomes within about 240 stool samples collected from 127 individuals hospitalized with COVID-19 between April 2020 and May 2021, 79 of whom had severe disease and 48 of whom had moderate disease. As they report in Genome Medicine, the researchers uncovered 48 bacterial species linked to severe disease, including declines in Fusicatenibacter saccharivorans and Roseburia hominis —reductions in which have been linked previously to long COVID, suggesting to them that a gut microbiome disturbance could precede the development of Long COVID. The researchers also found differences in microbial pathways between COVID-19 patients with differing disease courses that indicated bile acid and short-chain fatty acid levels may be altered in severe COVID-19. "Here, we show that the gut microbiome differentiates individuals with a more severe disease course after infection with COVID-19 and offer several tractable and biologically plausible mechanisms through which gut microbial communities may influence COVID-19 disease course," the researchers write.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.