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Good News, HapMap: We Still Need You

Dan Koboldt has a blog post at MassGenomics about how HapMap data is still useful, despite concerns that it would be made obsolete by the 1,000 Genomes Project. Koboldt reports on a talk he attended by the University of Chicago's Wei Zhang, whose group is "still leveraging the HapMap resource in numerous ways to better understand the relationship between genotype and phenotype." Koboldt sums up a number of efforts described by Zhang, including correlating gene expression and genotype, studying isoform variation, measuring tox profiles of anti-cancer drugs, and more. He adds that "efforts are currently under way at the University of Chicago to measure two more cell phenotypes on the HapMap samples" -- microRNA expression and DNA methylation.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.