Skip to main content
Premium Trial:

Request an Annual Quote

Off to Get More Floss

Severe gum disease might have more to do with the microbiome of someone's mouth than their genetics, the Washington Post reports.

Researchers led by Manabu Morita from Japan's Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences analyzed the oral microbiomes and genotypes of individuals with and without periodontal disease. Periodontitis affects about 10 percent of the global population, the Post notes.

As they reported in the International Journal of Environmental Research and Public Health, Morita and his colleagues found that members of the Lactobacillaceae and Desulfobulbacea families and Porphyromonas gingivalis were only present among individuals with periodontitis. At the same time, they noted no differences in SNP frequencies between the groups, hinting that the oral microbiome might have a greater influence on gum disease than genetics.

"In a way, that’s good news: People cannot change their genetic makeup, but they can influence their mouth microbiome through oral hygiene," the Post writes.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.