Investigators from Spain propose an outsized role for COVID-19 super-spreaders based on variants in more than 4,700 SARS-CoV-2 genome sequences. Although the sequence identity across the SARS-CoV-2 genomes was high, exceeding 99.9 percent, the team proposed two main SARS-CoV-2 haplogroups originating in Asia, along with more than 160 viral strains spanning the globe.