A team from Russia, China, Germany, and elsewhere share results from single-cell RNA sequencing- and bulk RNA-seq-based analyses of gene expression in samples from different brain regions in hundreds of humans, chimpanzees, bonobos, and rhesus macaques. With data on 33 anatomical brain regions in samples from 422 individuals, including more than 88,000 individual cells from three brain regions, the researchers saw more pronounced gene expression shifts in non-neuronal cells in the human lineage.