Skip to main content
Premium Trial:

Request an Annual Quote

Gene Set Could Identify Patients With Post-Treatment Lyme Disease

Researchers from Icahn School of Medicine at Mount Sinai and Johns Hopkins University have identified a set of genes whose expression patterns could indicate long-term Lyme disease. About 30,000 cases of Lyme disease, which is a tickborne illness, are reported each year to the US Centers for Disease Control and Prevention and 10 percent to 20 percent of affected people develop long-term symptoms. In their new study appearing in Cell Reports Medicine, the researchers collected blood samples from more than 150 people with post-treatment Lyme disease (PTLD) for RNA-seq analysis. When they compared the gene expression profiles of the PTLD individuals to those from 72 individuals with acute Lyme disease and 44 uninfected individuals, the researchers uncovered differences in gene expression between the groups. Using machine learning, they homed in on a set of 35 genes that could be used as a classifier for PTLD. "We wanted to understand whether there is a specific immune response that can be detected in the blood of patients with long-term Lyme disease to develop better diagnostics for this debilitating disease. There still remains a critical unmet need, as this disease so often goes undiagnosed or misdiagnosed," senior author Avi Ma'ayan from Mount Sinai says in a statement.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.