Skip to main content
Premium Trial:

Request an Annual Quote

Exercise's Epigenetic Effects

Exercise can exert an effect on the epigenetic status of enhancers, according to researchers from the Karolinska Institutet.

As they report in Epigenetics, the Karolinska's Carl Johan Sundberg and his colleagues recruited 23 volunteers to undergo exercise training for three months — though just on one leg. That way, notes Gretchen Reynolds at the New York Times Well blog, other factors influencing methylation patterns would be controlled for.

The researchers compared muscle biopsies taken from the exercised and unexercised legs both before and after training. From this, they noted differential DNA methylation on enhancers and changes in gene expression of muscle-cell related genes. For instance, they observed that the differentially methylated sites were overrepresented for functional categories like cellular carbohydrate metabolism regulation and structural remodeling. This suggested to the researchers that transcriptional changes in skeletal muscle due to exercise are linked to DNA methylation changes.

"Through endurance training — a lifestyle change that is easily available for most people and doesn’t cost much money," first author Maléne Lindholm tells the Well blog, "we can induce changes that affect how we use our genes and, through that, get healthier and more functional muscles that ultimately improve our quality of life."

The Scan

Support for Moderna Booster

An FDA advisory committee supports authorizing a booster for Moderna's SARS-CoV-2 vaccine, CNN reports.

Testing at UK Lab Suspended

SARS-CoV-2 testing at a UK lab has been suspended following a number of false negative results.

J&J CSO to Step Down

The Wall Street Journal reports that Paul Stoffels will be stepping down as chief scientific officer at Johnson & Johnson by the end of the year.

Science Papers Present Proteo-Genomic Map of Human Health, Brain Tumor Target, Tool to Infer CNVs

In Science this week: gene-protein-disease map, epigenomic and transcriptomic approach highlights potential therapeutic target for gliomas, and more