English bulldogs have such low genetic diversity that researchers are unsure whether their health can be improved without crossing them with another breed, LiveScience reports.

English Bulldogs, known for their squishy faces and wrinkly coats, are prone to breathing, skin, and other issues. The breed all descends from a founder population of 68 individuals and underwent selective breeding for certain traits.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.