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Early Malaria Vaccine Results

A new vaccine for malaria has shown high efficacy in a small trial, the Guardian reports, noting that malaria kills about 400,000 people, mostly children, each year.

It adds that scientists have been working on a malaria vaccine for about a century. According to the Guardian, there is one from GlaxoSmithKline called Mosquirix being piloted in a few countries in Africa, but it is only 39 percent effective in preventing malaria.

Now in a small trial of 450 children in Burkina Faso, a new vaccine developed by researchers at the University of Oxford was between 71 percent and 77 percent effective in preventing malaria, as they report in a preprint at the Lancet. This makes it, the BBC notes, the first malaria vaccine to meet the World Health Organization's goal of having at least 75 percent efficacy.

Principal investigator Halidou Tinto from Clinical Research Unit of Nanoro, Burkina Faso, says in a statement, according to CNN, that the results are "very exciting," and adds that they are looking forward to a phase III trial.

According to the Guardian, the researchers have an agreement in place with the Serum Institute of India to manufacture the vaccine at low cost.

The Scan

Sick Newborns Selected for WGS With Automated Pipeline

Researchers successfully prioritized infants with potential Mendelian conditions for whole-genome sequencing or rapid whole-genome sequencing, as they report in Genome Medicine.

Acne-Linked Loci Found Through GWAS Meta-Analysis

Researchers in the European Journal of Human Genetics find new and known acne vulgaris risk loci with a genome-wide association study and meta-analysis, highlighting hair follicle- and metabolic disease-related genes.

Retina Cell Loss Reversed by Prime Editing in Mouse Model of Retinitis Pigmentosa

A team from China turns to prime editing to correct a retinitis pigmentosa-causing mutation in the PDE6b gene in a mouse model of the progressive photoreceptor loss condition in the Journal of Experimental Medicine.

CRISPR Screens Reveal Heart Attack-Linked Gene

Researchers in PLOS Genetics have used CRISPR screens to home in on variants associated with coronary artery disease that affect vascular endothelial function.