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DNA Biobank Developed for French Kidney Donors, Recipients

In the European Journal of Human Genetics, a team from the University of Nantes shares findings from a genetic- and clinical annotation-based analysis of the "Kidney Transplantation-Genomics Investigation of Essential clinical outcomes" (KiT-GENIE) biobank, which was developed from a clinical database on kidney donors and recipients in Nantes from 2002 to 2018. The biobank contains DNA samples, SNP genotyping profiles, and human leukocyte antigen data — coupled with extensive clinical data — for more than 1,900 kidney donors and nearly 2,300 kidney transplant recipients in France, the researchers say, making it possible to explore genetic and immune factors affecting graft survival, rejection patterns, disease recurrence, and other outcomes following kidney transplantation. "KiT-GENIE constitutes one of the largest kidney transplantation genetic cohorts worldwide to date," they write, adding that the biobank "offers a unique opportunity to explore the genetic architecture of different post-transplant outcomes in order to improve their understanding, prevention, management, prediction, and treatment."

The Scan

International Team Proposes Checklist for Returning Genomic Research Results

Researchers in the European Journal of Human Genetics present a checklist to guide the return of genomic research results to study participants.

Study Presents New Insights Into How Cancer Cells Overcome Telomere Shortening

Researchers report in Nucleic Acids Research that ATRX-deficient cancer cells have increased activity of the alternative lengthening of telomeres pathway.

Researchers Link Telomere Length With Alzheimer's Disease

Within UK Biobank participants, longer leukocyte telomere length is associated with a reduced risk of dementia, according to a new study in PLOS One.

Nucleotide Base Detected on Near-Earth Asteroid

Among other intriguing compounds, researchers find the nucleotide uracil, a component of RNA sequences, in samples collected from the near-Earth asteroid Ryugu, as they report in Nature Communications.