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Dementia Risk Ticks Up in Individuals With Multiple Long-term Conditions

For a paper appearing in JAMA Network Open, a team from the University of Oxford, University of Exeter, and University of Hamburg uncover apparent ties between dementia risk and "multimorbidity" involving other diseases. Based on data for 206,960 participants followed for up to 15 years after their enrollment in the UK Biobank between 2006 and 2010, including the presence of absence of high-risk apolipoprotein epsilon 4 variants linked to genetic risk of Alzheimer's, the researchers documented increased dementia incidence in individuals diagnosed with two or more long-term health conditions. Over the follow-up time, they saw a 63 percent rise in dementia risk in individuals with multimorbidity, even after adjusting for genetic risk, age, and other factors, although some co-occurring conditions boosted dementia risk more than others. "This cohort study found that multimorbidity was associated with increased risk of incident dementia," they write, adding that such risk "was highest in women with hypertension, diabetes, and CHD or with pain, osteoporosis, and dyspepsia disease clusters in men with diabetes and hypertension or with CHD, hypertension, and stroke disease clusters."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.