Skip to main content
Premium Trial:

Request an Annual Quote

Chromatin Deacetylation Analysis Points to Potential Protective Effects During Mitosis

A team from Vienna BioCenter, the University of Vienna, and other centers characterize the material properties of chromosomes, identifying protective features found during the chromatin phase transition of mitotic cell division. As they report in a new study in Nature, the researchers relied on molecular tagging, genotyping, cell sorting, fluorescence imaging, and small interfering RNA experiments to track the consequences of mitotic chromatin deacetylation in dividing human cells, demonstrating that deacetylation spares mitotic chromosomes from being speared by mitotic microtubules. "Deacetylation-mediated compaction of chromatin forms a structure dense in negative charge and allows mitotic chromosomes to resist perforation by microtubules as they are pushed to the metaphase plate," they report. "By contrast, hyperacetylated mitotic chromosomes lack a defined surface boundary, are frequently perforated by microtubules, and are prone to missegregation."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.