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Certain P-Tau Biomarker Differentiates Alzheimer's Disease, Other Tauopathies

Specific phospho-tau (p-tau) antibodies can differentiate Alzheimer's disease brains, even from brains affected by other tauopathies, a new study has found. This suggests, the researchers add, that a certain form of p-tau could represent a biomarker for the condition. In a new study appearing in ACS Chemical Neuroscience, researchers from North Carolina Central University and Duke University Medical School used a tau antibody screening approach to analyze post-mortem brain samples from individuals with and without Alzheimer's disease. They uncovered a number of p-taus — including the known biomarkers p-tau181 and p-tau217 — that could distinguish Alzheimer's disease brains from brains from unaffected individuals. But one, p-tau198, could not only differentiate brains from individuals with Alzheimer's disease from controls but could also distinguish samples from individuals with Alzheimer's disease from those with related diseases like progressive supranuclear palsy and corticobasal degeneration. Further, p-tau198 could differentiate samples from individuals with mild cognitive impairment and cognitively normal brains. "Our work provides a new avenue for developing diagnosis and differentiation tools for AD and related tauopathies," the researchers wrote.

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.