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Stanford and Duke University researchers propose a CRISPR-Cas13-based strategy called "prophylactic antiviral CRISPR in human cells" (PAC-MAN) for combating influenza A viruses and coronaviruses such as SARS-CoV-2. The approach relies on RNA-guided inhibition and breakdown of the RNA making up the genomes of these viruses, the team says, and uses CRISPR RNAs aimed at conserved genome regions.

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