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An international team led by investigators in Germany tracks messenger RNA expression and translation in 80 human hearts. Using RNA sequencing, Ribo-seq, totRNA-seq, proteomics, and other approaches, the researchers profiled mRNA levels, ribosomal footprints, circular RNAs, proteins, microproteins, and more in left ventricular cardiac tissue samples from 65 individuals with dilated cardiomyopathy and 15 without, following up on their human heart results in cell line and mouse models.

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