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Cardiac Structure, Function Changes Linked to Schizophrenia Risk Scores

For a paper in Lancet Psychiatry, a King's College London-led research group presents findings from an observational study linking schizophrenia polygenic risk scores (PRS) to altered cardiac features and structural differences. With data for nearly 32,300 UK Biobank participants with available schizophrenia PRS profiles, diagnostic data, and cardiac magnetic resonance imaging tests, the investigators found that genetic risk for schizophrenia was inversely associated with enhanced cardiac volume, higher absolute peak diastolic strain rates, and several other heart structure or function features, along with potential ties to inflammatory and TGF-beta pathway activity. "Reduced absolute peak diastolic strain rates indicate increased myocardial stiffness and diastolic dysfunction, which increases risk of cardiac disease," the authors explain, suggesting that "genetic risk for schizophrenia is associated with cardiac structural changes that can worsen cardiac outcomes."

The Scan

Open Pediatric Brain Tumor Atlas Team Introduces Genomic Data Collection, Analytical Tools

A study in Cell Genomics outlines open-source methods being used to analyze and translate whole-genome, exome, and RNA sequence data from the Pediatric Brain Tumor Atlas.

Neurological Outcomes Linked to Innate Immune Features After Cardiac Arrest

Researchers reporting in Med dig into immune features found a few hours after cardiac arrest that correspond with neurological outcomes.

Mouse Study Finds Circadian Rhythm-Related Gene Expression Changes Linked to Sleep Apnea

A paper in PLOS Biology reveals tissue-specific circadian rhythm and gene expression patterns in an intermittent hypoxia-based mouse model of obstructive sleep apnea.

Polygenic Risk Score to Predict Preeclampsia, Gestational Hypertension in Pregnant Women

Researchers in Nature Medicine provide new mechanistic insights into the development of hypertensive disorders of pregnancy, which may help develop therapeutics.