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Cancers Containing NRG1-Fusions Show Scant Co-Occurring Mutations

In a paper appearing in the Journal of Molecular Diagnostics, a team from Labcorp, OmniSeq, Personal Genome Diagnostics, Illumina, and elsewhere tally fusions involving the NRG1 gene in thousands of cancer samples. The researchers did RNA sequencing on nearly 4,400 fresh frozen paraffin-embedded tumor samples from tumors with relatively low levels of known driver mutations, uncovering NRG1 fusions in samples from 17 patients with non-small cell lung cancer, breast cancer, colorectal cancer, or other cancer types. These included fusions involving several different NRG1 introns and 19 other genes, including 11 genes not found in NRG1 fusions in prior cancer studies. "The overall lack of co-occurring drivers highlights the importance of identifying NRG1 gene fusions, as these patients are unlikely to harbor other targetable alterations," the authors report, noting that RNA sequencing "increases the detection rate for NRG1 fusions and offers another potential therapy option for patients with advanced cancer."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.