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Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Investigators from Italy and the US explore cancer patient experiences related to immune checkpoint inhibitor (ICI) immunotherapy treatment for a review and meta-analysis appearing in JAMA Network Open. With data for more than 18,700 patients from almost three dozen prior randomized clinical trials, the team analyzed patient-reported outcomes after treatment using ICI alone or in combination with other therapies. Relative to patients who did not receive ICI treatment, the authors found that ICI-treated patients tended to report higher quality of life and longer stretches before their quality of life deteriorated. "The results of this meta-analysis demonstrate a favorable association of ICIs, with patient quality of life compared with control groups that did not contain immunotherapy across a large spectrum of solid tumors, "the authors report, adding that this benefit "was particularly evident when ICIs were administered as monotherapy."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.