Skip to main content
Premium Trial:

Request an Annual Quote

Breath-Based Biomarkers for Tuberculosis Diagnosis

Researchers from France and Columbia have identified tuberculosis-related molecules in exhaled breath condensate (EBC), pointing to a new noninvasive approach for diagnosing the disease at the point of care. TB, which is caused the pathogen Mycobacterium tuberculosis, remains a key cause of death worldwide. Still, an estimated one-third of TB cases go undiagnosed, in part because most tests rely on sputum samples, which can be difficult to obtain and have low diagnostic sensitivity in children, HIV-infected individuals, and patients with extrapulmonary TB. With the goal of developing a non-sputum-based TB diagnostic, the researchers examined whether pulmonary TB could be detected in EBC samples. As reported in Nature Communications this week, they show that M. tuberculosis-specific lipids lipoarabinomannan lipoglycan, and proteins in EBC can be used to differentiate TB patients from controls, either healthy or with community-acquired bacterial pneumonia. Notably, the biomarkers could also be used to track the longitudinal effects of antibiotic treatment in pediatric TB patients. The findings, the researchers write, "indicate that EBC analysis can potentially facilitate clinical diagnosis of TB across patient populations and monitor treatment efficacy."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.