Skip to main content
Premium Trial:

Request an Annual Quote

Blood Proteome Changes Found Among Long COVID Patients

A vasculo-proliferative process may contribute to long COVID, according to a new study appearing in the Journal of Translational Medicine. Researchers in Canada analyzed the plasma proteomes of patients with mild or severe acute COVID-19, patients with long COVID, and healthy individuals. They uncovered differences in the proteomes of the long COVID patients suggesting that their natural killer cells shifted their phenotype from resting to active and that their neutrophils are more likely to form extracellular traps. The researchers likewise found signaling pathway changes, including evidence that a vascular proliferative state linked to the hypoxia inducible factor 1 pathway could influence the transition from acute COVID-19 to long COVID. "When we identify these signaling patterns within the blood plasma, we can then take the information and screen drug databases to better understand which drugs would be best to target the changes we identified in long COVID patients," senior author Douglas Fraser from Ontario's London Health Sciences Centre says in a statement. "With this understanding, the identified drugs may be used in future long COVID clinical trials."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.