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Antimicrobial 'Resistome' Proposed from Metagenomic Microbial Sequence Set

In PLOS Biology, researchers at the Technical University of Denmark tally the antimicrobial resistance genes (ARG) found in metagenomic sequences spanning about 214,100 samples representing nearly 800 host types profiled for more than 6,300 prior projects. With computational analyses focused on ARGs, 16S ribosomal RNA genes, and 18S rRNA genes in the metagenomic sequences, obtained from the European Nucleotide Archive database, the team began teasing apart ARG features and sampling type-related ARG patterns. "With this data resource," the authors suggest, "we have taken a step towards enabling the scientific community to utilize the wealth of information in these metagenomic samples to broaden our understanding of the dissemination of antimicrobial resistance and changes in microbiomes at both local and global scales through time and environments."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.