Skip to main content
Premium Trial:

Request an Annual Quote

Antimicrobial Resistance Study Highlights Key Protein Domains

In PLOS Genetics, investigators in the US and Spain consider contributors to antimicrobial resistance (AMR) in bacterial populations, focusing on the Vibrio cholerae protein OmpU, an outer membrane porin in the cholera-causing pathogen. "This porin is directly associated with the emergence of toxigenic clades and confers resistance to numerous host antimicrobials," they write, noting that their analyses focused on naturally occurring OmpU allelic variants that turned up in V. cholerae samples collected environmentally. The team tracked down two main porin clusters based on genetic variability and phylogenetics, using a genetic diversity-informed analytical framework, high-throughput screening of OmpU-mutant V. cholerae strains, and phenotypic microarrays to find and characterize OmpU variants and protein domains contributing to AMR and/or resistance to host bile or peptides. "Overall, our assessment of natural allelic variations uncovered functional protein domains associated with AMR," the authors report, "shedding light on the evolutionary processes leading to the emergence of this phenomenon."

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.