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Analysis for the Long Term

The US National Institutes of Health is investing more than $1 billion to study the long-term effects of COVID-19, Nature News reports.

A portion of people who have had COVID-19 have reported lingering symptoms such as lasting fatigue and shortness of breath as well as concentration problems and depression, which the NIH has termed post-acute sequelae of SARS-CoV-2 infection, or PASC, as Nature News notes. With its NIH PASC Initiative, the agency aims to learn more about these symptoms and how to prevent or treat them, as agency director Francis Collins writes on his blog page.

According to Nature News, one of the projects the initiative will tackle is a recovery-tracking program to follow patients to see whether or not they develop long COVID, while another project will build a repository of biospecimens from PASC patients — including blood, urine, feces, and cerebrospinal fluid — that researchers will be able to use in future studies.

The Scan

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.

Using Bees to Gain Insights into Urban Microbiomes

As bees buzz around, they pick up debris that provides insight into the metagenome of their surroundings, researchers report in Environmental Microbiome.

Age, Genetic Risk Tied to Blood Lipid Changes in New Study

A study appearing in JAMA Network Open suggests strategies to address high lipid levels should focus on individuals with high genetic risk and at specific ages.

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.