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Advanced Pancreatic Cancer Survival Found Following Targeted Treatments Matched to Genomic Alterations

For a paper in NPJ Genomic Medicine, a team from the Medical College of Wisconsin, the University of Nebraska, and other centers in the US and France present findings from an advanced pancreatic cancer pilot study focused on biomarker-based personalized medicine options. Starting with data for more than 6,800 patients in a University of California, San Diego, database, the investigators focused on 18 advanced pancreatic adenocarcinoma patients with targeted treatment therapies found by genomic profiling, including five patients who received targeted treatment as a first-line therapy and 13 patients given them as second-line targeted agents. High biomarker-targeted treatment matching scores coincided with stretched-out overall survival times, they found, with higher clinical benefit rates in patients who received first-line targeted treatment. "The results of this analysis suggest that, when genomic-directed matched therapy can achieve a high degree of matching, and especially in first-line settings, clinical outcomes can be improved, even with regimens that exclude chemotherapy," the authors report, adding that the findings "reflect the need for implementation of multi-omic and functional testing for all patients with advanced pancreatic cancer, perhaps earlier in the course of disease, to further identify actionable alterations."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.