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Accuracy of Thyroid Fine-Needle Biopsy Unchanged Over 40 Years, Study Finds

Despite updates to the use of thyroid fine-needle biopsy (FNB) for thyroid nodule diagnosis over the past few decades, the accuracy of the procedure has remained largely unchanged though it continues to be a reliable test for thyroid cancer diagnosis, according to a study in JAMA Surgery this week. Since thyroid FNB became a key part of thyroid malignancy diagnosis in the late 1970s, there have been numerous improvements in the way the procedure is performed including the use of ultrasound guidance, rapid on-site cytopathologic evaluation, and refinements to cytopathology sample preparation and the interpretation of results. Yet the impact these changes have had on the accuracy of FNB testing is not known. To investigate, a team led by scientists from the University of Wisconsin-Madison performed a systematic review and meta-analysis of relevant peer-reviewed research and clinical trial reports obtained from PubMed, SCOPUS, and the Cochrane Central Register of Controlled Trials between 1975 and 2020. They find that the accuracy of thyroid FNB has not significantly changed over time, as the overall sensitivity and specificity estimates for the procedure at 85.6 percent and 71.4 percent, respectively. Still, "FNB remains an efficient, relatively noninvasive, and affordable method for determining the next step in the management of undifferentiated thyroid nodule," the authors write

The Scan

ChatGPT Does As Well As Humans Answering Genetics Questions, Study Finds

Researchers in the European Journal of Human Genetics had ChatGPT answer genetics-related questions, finding it was about 68 percent accurate, but sometimes gave different answers to the same question.

Sequencing Analysis Examines Gene Regulatory Networks of Honeybee Soldier, Forager Brains

Researchers in Nature Ecology & Evolution find gene regulatory network differences between soldiers and foragers, suggesting bees can take on either role.

Analysis of Ashkenazi Jewish Cohort Uncovers New Genetic Loci Linked to Alzheimer's Disease

The study in Alzheimer's & Dementia highlighted known genes, but also novel ones with biological ties to Alzheimer's disease.

Tara Pacific Expedition Project Team Finds High Diversity Within Coral Reef Microbiome

In papers appearing in Nature Communications and elsewhere, the team reports on findings from the two-year excursion examining coral reefs.