It's a balancing act, to be sure, to get and keep a core lab facility up-to-date with new technologies and services. There are many facets of running a shared resource that need to be considered when a core looks into acquiring or upgrading a tool or changing a service. There's the gamble of whether that new technology will be the one to take off or not — after all, no one wants to invest time and money in someone's Betamax and miss out on VHS.

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In PLOS this week: new gene linked to ocular coloboma, new statistical model for interrogating gene expression networks, and more.

With a new collection, PLOS highlights negative results it has published.

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