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USPTO Publishes Two RNAi-Related Patent Applications: Jun 26, 2008

Title: Compositions and Methods for the Treatment and Prevention of Neoplastic Disorders
Number: 20080145313
Filed: Aug. 30, 2007
Inventor: James Watson, Genesis Research & Development
According to the patent application’s abstract, the invention comprises “compositions for the treatment and/or prevention of cancer in a mammal by means of RNA interference … together with methods for the use of such compositions. The compositions comprise a small interfering nucleic acid molecule that suppresses expression of a target gene that is involved in an energy metabolism pathway, such as the glycolysis pathway, within a tumor cell; is involved in the biosynthesis of nucleotides in glycogen metabolism or is an electron carrier that works with ATP to provide metabolic energy; or is involved in transport of sugars, amino acids, and/or water-soluble vitamins, control of intercellular pH, or drug transport within a tumor cell.”

Title: Positionally Modified siRNA Constructs
Number: 20080146788
Filed: March 3, 2004 PCT Filed: March 3, 2004
Inventor: Balkrishen Bhat, Isis Pharmaceuticals
The invention, the patent application’s abstract states, provides “oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment, the oligomeric compounds comprise double-stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.”

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