Skip to main content
Premium Trial:

Request an Annual Quote

USPTO Publishes Two RNAi-Related Patent Applications: Jul 6, 2006


Title: RNA Interference-Mediated Inhibition of Histone Deacetylase Gene Expression Using Short Interfering Nucleic Acid

Number: 20060148743

Filed: Sept. 1, 2005

Lead Inventor: Vasant Jadhav, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating histone deacetylase gene expression using short-interfering nucleic acid molecules," the patent application's abstract states. "In particular, the instant invention features small nucleic acid molecules … used to modulate the expression of HDAC genes, such as HDAC genes associated with the maintenance or development of diseases, disorders, traits, and conditions in a subject or organism such as cancer, proliferative disease, and age-related disease."

Title: Polynucleotide Delivery to Cardiac Tissue

Number: 20060148742

Filed: Aug. 25, 2005

Lead Inventor: David Martin Kay, Baker Heart Research Institute

The patent application, its abstract states, cover "a method for delivering a polynucleotide to cardiac tissue, including substantially isolating the coronary venous circulation from systemic circulation, and introducing a polynucleotide into the isolated coronary venous circulation to effect localized transfection of cardiac tissue. The polynucleotide advantageously produces a therapeutic effect, such as increasing or decreasing the expression level of a protein in the cardiac tissue."

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.