Skip to main content
Premium Trial:

Request an Annual Quote

USPTO Publishes Two RNAi-Related Patent Applications: Jul 6, 2006


Title: RNA Interference-Mediated Inhibition of Histone Deacetylase Gene Expression Using Short Interfering Nucleic Acid

Number: 20060148743

Filed: Sept. 1, 2005

Lead Inventor: Vasant Jadhav, Sirna Therapeutics

"This invention relates to compounds, compositions, and methods useful for modulating histone deacetylase gene expression using short-interfering nucleic acid molecules," the patent application's abstract states. "In particular, the instant invention features small nucleic acid molecules … used to modulate the expression of HDAC genes, such as HDAC genes associated with the maintenance or development of diseases, disorders, traits, and conditions in a subject or organism such as cancer, proliferative disease, and age-related disease."

Title: Polynucleotide Delivery to Cardiac Tissue

Number: 20060148742

Filed: Aug. 25, 2005

Lead Inventor: David Martin Kay, Baker Heart Research Institute

The patent application, its abstract states, cover "a method for delivering a polynucleotide to cardiac tissue, including substantially isolating the coronary venous circulation from systemic circulation, and introducing a polynucleotide into the isolated coronary venous circulation to effect localized transfection of cardiac tissue. The polynucleotide advantageously produces a therapeutic effect, such as increasing or decreasing the expression level of a protein in the cardiac tissue."

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.