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USPTO Publishes Three RNAi-Related Patents

Title: microRNA Molecules
Numbers: 7,232,806
Filed: Sept. 27, 2002 PCT Filed: Sept. 27, 2002
Lead Inventor: Thomas Tuschl, Max Planck
“In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing,” the patent’s abstract states. “Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs. We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRNA, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.”

Title: Methods of Modulating IKK-alpha Activity
Numbers: 7,235,654
Filed: Dec. 8, 2003
Lead Inventor: Jun Li, Boehringer Ingelheim
According to the patent’s abstract, the invention comprises a method for “modulating NF-kappa B-dependent gene transcription in a cell comprised of modulating IKK-alpha protein activity in the cell. The … invention also provides siRNA compositions and methods thereof for modulating NF-kappa B-dependent gene transcription.”

Title: Methods of Inhibiting Manganese-Containing Superoxide Dismutase 2 (MnSOD)
Numbers: 7,232,808
Filed: Aug. 1, 2005
Lead Inventor: Douglas Trask, University of Iowa
The invention “provides RNA molecules, e.g., antisense, RNAi, or siRNA, specific for MnSOD, and further provides methods of reducing expression of MnSOD in cells, e.g., cancer cells.”

The Scan

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In a preprint, a researcher describes his recovery of viral sequences that had been removed from a common database.

Rare Heart Inflammation Warning

The Food and Drug Administration is adding a warning about links between a rare inflammatory heart condition and two SARS-CoV-2 vaccines, Reuters reports.

Sandwich Sampling

The New York Times sent tuna sandwiches for PCR analysis.

Nature Papers Describe Gut Viruses, New Format for Storing Quantitative Genomic Data, More

In Nature this week: catalog of DNA viruses of the human gut microbiome, new dense depth data dump format to store quantitative genomic data, and more.