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USPTO Publishes Three RNAi-Related Patents

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Title: microRNA Molecules
 
Numbers: 7,232,806
 
Filed: Sept. 27, 2002 PCT Filed: Sept. 27, 2002
 
Lead Inventor: Thomas Tuschl, Max Planck
 
“In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide RNAs, respectively, that function as key regulators of developmental timing,” the patent’s abstract states. “Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs. We show that many more 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates, and that some of these novel RNAs, similar to let-7 stRNA, are also highly conserved. This suggests that sequence-specific post-transcriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated.”
 

 
Title: Methods of Modulating IKK-alpha Activity
 
Numbers: 7,235,654
 
Filed: Dec. 8, 2003
 
Lead Inventor: Jun Li, Boehringer Ingelheim
 
According to the patent’s abstract, the invention comprises a method for “modulating NF-kappa B-dependent gene transcription in a cell comprised of modulating IKK-alpha protein activity in the cell. The … invention also provides siRNA compositions and methods thereof for modulating NF-kappa B-dependent gene transcription.”
 

 
Title: Methods of Inhibiting Manganese-Containing Superoxide Dismutase 2 (MnSOD)
 
Numbers: 7,232,808
 
Filed: Aug. 1, 2005
 
Lead Inventor: Douglas Trask, University of Iowa
 
The invention “provides RNA molecules, e.g., antisense, RNAi, or siRNA, specific for MnSOD, and further provides methods of reducing expression of MnSOD in cells, e.g., cancer cells.”

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