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USPTO Publishes Three RNAi-Related Patent Applications: Feb 16, 2006

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Title: Methods for Reducing or Preventing Localized Fibrosis Using siRNA

Number: 20060030538

Filed: July 18, 2005

Inventor: Marc Hendriks, Medtronic

The patent application, its abstract states, covers "methods for reducing or preventing localized fibrosis in a localized tissue region using siRNA technology."


Title: Medical Devices and Methods for Reducing Localized Fibrosis

Number: 20060029636

Filed: July 18, 2005

Inventor: Marc Hendriks, Medtronic

According to its abstract, the patent application covers "medical devices and methods for reducing localized fibrosis at the site of the medical device."


Title: Composition and Method for Introduction of RNA Interference Sequences into Targeted Cells and Tissues

Number: 20060030003

Filed: July 21, 2005

Inventor: Michael Simon

The patent application, its abstract states, covers "a composition and method ... by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues for the purpose of inhibiting gene expression and protein production in those cells and tissues. Intracellular introduction of the small interfering RNA nucleotide sequences is accomplished by the internalization of a target cell specific ligand bonded to a RNA binding protein to which a double-stranded RNA containing a small interfering RNA nucleotide sequence is adsorbed. The ligand is specific to a unique target cell surface antigen," the abstract notes. "The ligand is either spontaneously internalized after binding to the cell surface antigen. If the unique cell surface antigen is not naturally internalized after binding to its ligand, internalization is promoted by the incorporation of an arginine-rich peptide, or other membrane permeable peptide, into the structure of the ligand or RNA binding protein or attachment of such a peptide to the ligand or RNA binding protein. The composition and method are practiced in whole living mammals, as well as cells living in tissue culture."

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