Title: Compositions and Methods for Inhibiting Expression of Anti-Apoptotic Genes
Filed: Sept. 15, 2005
Inventor: Hans-Peter Vornlocher
The invention "relates to a double-stranded ribonucleic acid for inhibiting the expression of an anti-apoptotic gene, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of an apoptotic gene, such as a Bcl gene," the patent application's abstract states. "The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of an anti-apoptotic gene using the pharmaceutical composition; and methods for inhibiting the expression of an anti-apoptotic gene in a cell."
Title: RNA Interference in Respiratory Epithelial Cells
Filed: July 11, 2005
Lead Inventor: Paul McCray, University of Iowa
The invention "is directed to small interfering RNA molecules targeted against a gene of interest in respiratory epithelial cells, and methods of using these RNA molecules," the patent application's abstract states.
Title: Methods for Delivery of Nucleic Acids
Filed: May 6, 2003 PCT Filed: May 6, 2003
Inventor: C. Satishchandran, Nucleonics
According to the patent application's abstract, "this invention features methods and compositions for delivery of nucleic acids (e.g., DNA, RNA, PNA, and hybrids thereof) to cells. The nucleic acid delivery complexes of the invention permit biologically active nucleic acids to be delivered to cells and organisms in vitro and in vivo in a manner and form that allows the nucleic acids to carry out their desired biological function."