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USPTO Publishes Six RNA-Related Patent Applications

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Title: Reduction of Hair Growth

Number: 20060135461

Filed: Dec. 21, 2005

Lead Inventor: Natalia Botchkareva, Gillette

According to the patent application's abstract, "mammalian hair growth is reduced by topically applying a composition including a survivin inhibitor."


Title: Methods and Compositions for RNA Interference

Number: 20060135456

Filed: Nov. 23, 2004

Lead Inventor: Gregory Hannon, Cold Spring Harbor Laboratory

The invention, the patent application's abstract states, "provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double-stranded RNA such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a portion of the gene to be inhibited (the 'target' gene)."


Title: Down-Regulation of Target Gene with PEI/Single-Stranded Oligonucleotide Sequences

Number: 20060135453

Filed: Jan. 30, 2004 PCT Filed: Jan. 30. 2004

Lead Inventor: Jean-Charles Bologna, Novartis

According to the patent application's abstract, the invention "provides methods for the down regulation of target genes by an RNA interference mechanism using short single stranded RNA and a cationic polymer, such as linear PEI."


Title: Methods and Compositions for Enhancing the Efficacy and Specificity of Single and Double Blunt-Ended siRNA

Number: 20060134787

Filed: Dec. 22, 2004

Lead Inventor: Phillip Zamore, University of Massachusetts

The invention provides "methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA," the patent application's abstract states. "The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured."


Title: Use of RNA Trans-Splicing for Generation of Interfering RNA Molecules

Number: 20060134658

Filed: Aug. 9, 2005

Inventor: Mariano Garcia-Blanco, Duke University

The patent application, its abstract states, covers "methods and compositions for generating novel nucleic acid molecules through trans-splicing that function to reduce the level of expression of a target RNA. The compositions of the invention include pre-trans-splicing molecules designed to interact with a target precursor messenger RNA molecule and mediate a trans-splicing reaction resulting in the generation of primary microRNAs, which are processed in the cell to molecules, referred to as mature miRNA duplex or short interfering RNAs, capable of producing gene silencing by RNA interference."


Title: siRNA Silencing of Apolipoprotein B

Number: 20060134189

Filed: Nov. 17, 2005

Lead Inventor: Ian MacLachlan, Protiva Biotherapeutics

"The invention provides nucleic acid-lipid particles comprising siRNA molecules that silence ApoB expression and methods of using such nucleic acid-lipid particles to silence ApoB expression," the patent application's abstract states.

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