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USPTO Publishes One RNAi-Related Patent Application: Jan 17, 2008

Title: Methods, Libraries, and Computer Program Products for Determining Whether siRNA-Induced Phenotypes are Due to Off-Target Effects
Number: 20080009012
Filed: July 6, 2007
Lead Inventor: Amanda Birmingham, Dharmacon (Thermo Fisher Scientific)
The patent application, its abstract states, claims “methods, libraries, and computer program products for determining whether a phenotype induced by a candidate siRNA for a target gene in an RNAi experiment is target specific or a false positive. Through the use of a control siRNA that has one or two seed sequences of six or seven bases in combination with a neutral scaffolding sequence, a distinction can be made between false positive and true positive analyses of functionality.”

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