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USPTO Publishes One RNAi-Related Patent

Title: Nanoparticle Delivery Vehicle
Number: 7,332,586
Filed: July 10, 2002
Lead Inventor: Stefan Franzen, North Carolina State University
The patent, its abstract states, claims “a nanoparticle delivery vehicle comprising a nanoparticle, an active agent, and a nuclear localization signal and methods of modulating gene expression and protein expression employing the nanoparticle delivery vehicle.”
This nanoparticle, the abstract adds, has “a diameter of about 30 nm or less” and contacts “a target cell … whereby an active agent is delivered to the nucleus of a target cell. Another representative method includes … a nanoparticle having a diameter greater than or equal to about 30 nm, an active agent, and a nuclear localization signal, [which contact] a target cell with the nanoparticle delivery vehicle, whereby an active agent is delivered to the cytoplasm of a cell.”

The Scan

Two J&J Doses

Johnson & Johnson says two doses of its SARS-CoV-2 vaccine provides increased protection against symptomatic COVID-19, CNN reports.

Pfizer-BioNTech Vaccine Response in Kids

The Pfizer-BioNTech SARS-CoV-2 vaccine in a lower-dose format appears to generate an immune response among children, according to the Washington Post.

Chicken Changes to Prevent Disease

The Guardian writes that researchers are looking at gene editing chickens to help prevent future pandemics.

PNAS Papers on Siberian Dog Ancestry, Insect Reproduction, Hippocampal Neurogenesis

In PNAS this week: ancestry and admixture among Siberian dogs, hormone role in fruit fly reproduction, and more.