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USPTO Publishes One Patent, Three Patent Applications Related to RNAi: Jul 31, 2008

Title: Lipid Nanoparticle-Based Compositions and Methods for the Delivery of Biologically Active Molecules
Number: 7,404,969
Filed: Oct. 24, 2006
Lead Inventor: Tongqian Chen, Sirna Therapeutics (Merck)
The invention “relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid molecules,” the patent’s abstract states. “Specifically, the invention relates to novel cationic lipids, microparticles, nanoparticles, and transfection agents that effectively transfect or deliver short interfering nucleic acid. The compositions described herein are generally referred to as formulated molecular compositions or lipid nanoparticles.

Title: Methods and Compositions Involving miRNA and miRNA Inhibitor Molecules
Number: 20080176766
Filed: Aug. 10, 2007
Lead Inventor: David Brown, Ambion (Asuragen)
The invention, the patent application’s abstract states, “concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the … invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.”

Title: Allele-Specific Silencing of Disease Genes
Number: 20080176812
Filed: Jan. 31, 2006
Lead Inventor: Beverly Davidson, University of Iowa
According to the patent application’s abstract, the invention “is directed to small interfering RNA molecules targeted against an allele of interest and methods of using these siRNA molecules.”

Title: siRNA Targeting Cyclin-Dependent Kinase Inhibitor 1B
Number: 20080177051
Filed: Oct. 30, 2007
Lead Inventor: Anastasia Khvorova, Dharmacon (Thermo Fisher Scientific)
“Efficient sequence-specific gene silencing is possible through the use of siRNA technology,” the patent application’s abstract states. “By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene-silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for CDKN1B.”

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