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USPTO Publishes One Patent, Four Patent Applications Related to RNAi: Aug 21, 2008

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Title: Cloning and Characterization of microRNAs from Rice
 
Number: 7,414,125
 
Filed: March 29, 2006
 
Lead Inventor: Jian-Kang Zhu, University of California, Riverside
 
The invention “provides new miRNAs in rice,” according to the patent’s abstract. Additionally, “the nucleic acids of the invention can be used to control gene expression in plants.”
 

 
Title: Highly Potent hsiRNA Mixtures and Method for Gene Splicing
 
Number: 20080194028
 
Filed: Feb. 14, 2005 PCT Filed: Feb. 14, 2005
 
Lead Inventor: George Tzertzinis, New England Biolabs
 
The patent application, its abstract states, claims a method of making and use a composition having “a plurality of dsRNA fragments with overlapping sequences, each fragment having a size in the range of 18-30 [nucleotides], such that the composition is formed by enzymatic digestion of one or more large dsRNAs and less than 2 nM of the composition is capable of specifically silencing expression of a target gene by at least 65 percent in transfected COS cells.”
 

 
Title: RNA-Mediated Interference to Control Disease in Terrestrial and Aquaculture Animals
 
Number: 20080194504
 
Filed: Feb. 4, 2005 PCT Filed: Feb. 4, 2005
 
Lead Inventor: David Kyle, Advanced Bionutrition
 
“The invention is directed to compositions [such as] feeds, feed supplements, and therapeutic products, and methods for inhibiting an animal pathogen using RNA interference technology,” according to the patent application’s abstract.
 

 
Title: Compositions and Methods for Inhibiting Viral Replication
 
Number: 20080194512
 
Filed: Dec. 19, 2007
 
Lead Inventor: Matthias John, Alnylam Europe (Alnylam Pharmaceuticals)
 
The invention, the patent application’s abstract states, “relates to a double-stranded ribonucleic acid having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least a part of a 3'-untranslated region of a strand RNA virus, such as HCV, as well as pharmaceutical compositions comprising the dsRNA together with a pharmaceutically acceptable carrier. The pharmaceutical compositions are useful for treating infections and diseases caused by the replication or activity of the [sense] strand RNA virus, as well as methods for inhibiting viral replication.”
 

 
Title: RNAi-Mediated Inhibition of Aquaporin 4 for Treatment of Ocular Neovascularization
 
Number: 20080194513
 
Filed: Jan. 28, 2008
 
Lead Inventor: Rajkumar Patil, Alcon
 
The patent application, its abstract states, claims “RNA interference … for inhibition of aquaporin 4 to treat conditions associated with neovascularization.”

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