Title: Immunostimulatory siRNA Molecules and Uses Thereof
Filed: June 30, 2005
Lead Inventor: Ian MacLachlan, Protiva Biotherapeutics
The invention "provides siRNA molecules and methods of using such siRNA molecules to modulate an immune response and to silence expression of a target gene," the patent application's abstract states.
Title: RNA Interference-Mediated Inhibition of Protein Tyrosine Phosphate-1B Gene Expression Using Short Interfering Nucleic Acid
Filed: Jan. 14, 2005
Lead Inventor: James McSwiggen, Sirna Therapeutics
The invention, the patent application's abstract states, "relates to compounds, compositions, and methods useful for modulating protein tyrosine phosphatase-1B gene expression using short interfering nucleic acid molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of PTP-1B gene expression and/or activity by RNA interference using small nucleic acid molecules. … Such small nucleic acid molecules are useful, for example, for treating, preventing, inhibiting, or reducing obesity, insulin resistance, diabetes in a subject or organism, and for any other disease, trait, or condition that is related to or will respond to the levels of PTP-1B in a cell or tissue, alone or in combination with other treatments or therapies."
Title: RNA Interference Pathway Genes as Tools for Targeted Genetic Interference
Filed: June 3, 2005
Lead Inventor: Craig Mello, University of Massachusetts
"Genes involved in double-stranded RNA interference are identified and used to investigate the RNAi pathway," the patent application's abstract states. "The genes and their products are also useful for modulating RNAi pathway activity."
Title: Methods and Products Related to the Production of Inner Ear Hair Cells
Filed: Jan. 24, 2005
Inventor: Zheng-Yi Chen, Massachusetts General Hospital (Sirna Therapeutics)
"The invention relates to the generation of inner ear sensory epithelial cells through the manipulation of the expression level or function of the genes and/or proteins involved in the retinoblastoma (Rb) pathway, particularly retinoblastoma family members, such as Rb1," the patent application's abstract states. "Methods for generating inner ear sensory epithelial cells and for restoring hearing or balance in a subject, therefore, are provided. The invention further relates to cell lines of inner ear sensory epithelial cells, such as progenitor, supporting or hair cells, where the expression level or function of the retinoblastoma genes and/or retinoblastoma proteins has been manipulated" with the use of an RNAi or siRNA molecule. "In addition to these methods, compositions of agents for use in or the cells produced by such methods provided are also included," the abstract adds. "Finally, the invention also relates to methods and compositions for the generation of inner ear sensory epithelial cells through the manipulation of Isl-1 alone or in combination with the manipulation of retinoblastoma gene and/or retinoblastoma protein."