Title: Methods for Treating Cancer Using Anti-Wnt2 Monoclonal Antibodies and siRNA
Filed: May 16, 2005
Lead Inventor: Liang You, University of California
The invention "relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2," the patent application's abstract states. "The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor."
Title: Compositions and Methods for Enhancing Delivery of Nucleic Acids into Cells and for Modifying Expression of Target Genes in Cells
Filed: May 4, 2005
Lead Inventor: Lishan Chen, Nastech Pharmaceutical
"Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells," the patent application's abstract states. "The transported nucleic acids are active in target cells as small inhibitory nucleic acids that modulate expression of target genes, mediated at least in part by RNA interference. The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered."
Title: RNA Interference Vectors
Filed: Aug. 20, 2004
Lead Inventor: Cheryl Bailey, Promega
According to the patent application's abstract, the invention "relates to gene-specific silencing through RNA interference, and in particular, to vectors for expressing RNAi molecules. In some embodiments, the present invention provides compositions and methods for inducible expression of RNAi molecules, and/or for long-term expression of RNAi molecules. Hence the compositions and methods described herein are suitable for regulatable and/or sustained gene-specific silencing in cells," the abstract states.
Title: Methods, Compositions, and Kits Comprising RNA for RNA Interference
Filed: June 23, 2005
Inventor: Gerald Zon, Applera
The invention, the patent application's abstract states, relates "to methods, compositions, and kits for reducing the amount of a target polynucleotide sequence. In some embodiments, block oligomers comprising peptide nucleic acids are hybridized to an anti-sense strand to form an anti-sense complex comprising regions with desirable thermodynamic characteristics. In some embodiments, the expression of a target messenger RNA is reduced in RNA interference experiments using anti-sense compositions comprising PNAs."