Title: Double-Stranded Oligonucleotides
Filed: Feb. 2, 2005
Inventor: Todd Woolf, Ipifini
"Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed" in the patent application, its abstract states. "The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the improved antisense oligomer compositions."
Title: SiRNA-Mediated Gene Silencing with Viral Vectors
Filed: Jan. 31, 2005
Lead Inventor: Beverly Davidson, University of Iowa (Sirna Therapeutics)
According to the patent application's abstract, the invention "is directed to viral vectors encoding small interfering RNA molecules targeted against a gene of interest, and methods of using these viral vectors."
Title: In Vivo Production of Small Interfering RNAs that Mediate Gene Silencing
Filed: July 12, 2002
Lead Inventor: Phillip Zamore, University of Massachusetts
"The invention provides engineered RNA precursors that when expressed in a cell are processed by the cell to produce targeted small interfering RNAs that selectively silence targeted genes (by cleaving specific mRNAs) using the cell's own RNA interference pathway," the patent application's abstract states. "By introducing nucleic acid molecules that encode these engineered RNA precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered RNA precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells."
Title: Lipid-Encapsulated Interfering RNA
Filed: June 7, 2005
Lead Inventor: Ian Mac Lachlan, Protiva Biotherapeutics
The invention, the patent application's abstract states, "provides lipid-based formulations for delivering, e.g., introducing, nucleic acid-lipid particles comprising an interference RNA molecule to a cell, and assays for optimizing the delivery efficiency of such lipid-based formulations. "
Title: Control of Gene Expression via Light-Activated RNA Interference
Filed: June 9, 2005
Lead Inventor: Simon Friedman, University of Missouri
"A method for controlling the spacing, timing and degree of gene expression that includes selecting a target mRNA, obtaining siRNA corresponding to the target mRNA, modifying the siRNA with a photo-labile group to inhibit RNA interference, introducing the modified siRNA into a cell, and selectively irradiating the cell with light having a predetermined wavelength," the patent application's abstract states. "A modified siRNA capable modulating gene expression that includes an siRNA that targets a predetermined complementary mRNA and at least one photo-labile group attached to said siRNA."