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USPTO Allows Claims in Mirna Patent Application on let-7


Mirna Therapeutics said this week that the US Patent and Trademark Office has issued a notice of allowance for claims in a company-controlled patent application related to the therapeutic use of the let-7 microRNA.

Mirna said that, along with collaborators at Yale University, it has shown that let-7 regulates "multiple cancer-related genes and pathways, influences the sensitivity of cancer cells to radiation and chemotherapy, and affects tumor development."

Additional work has demonstrated that altered expression of let-7 is important in cancer stem cell development and that the miRNA can inhibit metastasis.

The Scan

Rare Genetic Disease Partnership

A public-private partnership plans to speed the development of gene therapies for rare genetic diseases, Stat News writes.

Approval Sought for Alzheimer's Drug

The Wall Street Journal reports Eli Lilly has initiated a rolling submission to the US Food and Drug Administration to seek approval for its drug to treat Alzheimer's disease.

DNA Barcoding Paper Retracted

Science reports that a 2014 DNA barcoding paper was retracted after a co-author brought up data validity concerns.

Nature Papers Present Genomic Analysis of Bronze Age Mummies, Approach to Study Host-Pathogen Interactions

In Nature this week: analysis finds Tarim mummies had local genetic origin, and more.