University of Kentucky Team Publishes Data Linking Retinal Toxicity to 21-Mer siRNAs | GenomeWeb

By Doug Macron

Researchers from the University of Kentucky this month published data in Molecular Therapy showing that 21-nucleotide-long siRNAs cause retinal toxicity even if they are formulated for delivery into the cell, potentially providing insight into the abandonment of several siRNA drugs that had been in human testing as treatments for wet age-related macular degeneration.

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