Skip to main content
Premium Trial:

Request an Annual Quote

Two RNAi-Related Patent Applications Published by US Patent Office


Title: RNA Interference-Mediated Inhibition of Hepatitis B Virus Using Short Interfering Nucleic Acid (siNA). Number: 20030206887. Filed: Sept. 16, 2002. Lead Inventor: David Morrissey, Sirna Therapeutics.

The patent application’s abstract states that the invention covers “methods and reagents useful in modulating hepatitis B virus gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to short interfering nucleic acid or short interfering RNA molecules capable of mediating RNA interference against hepatitis B virus.”

Title: Nanometer-Sized Carrier Medium. Number: 20030206859. Filed: May 1, 2003. Lead Inventor: I-Wei Chen, University of Pennsylvania.

The invention, the patent application’s abstract states, “relates to a colloidal dispersion of amine-terminated silica particles having a narrowly controlled size range in an aqueous phase for diagnostic imaging, drug delivery, and gene therapy.”

The patent application also claims the colloidal dispersion “comprising at least one diagnostic or therapeutic agent coupled thereto.” This agent can be, among other things, “genetic material,” which includes “geno- mic DNA, cDNA, mRNA, and RNAi including antisense RNA and siRNA,” the application states.

The application also covers “methods of preparing surface-modified silica particles suitable for use in an aqueous colloidal carrier medium, for preparing a diagnostic or therapeutic agent for targeted delivery to specific anatomical structures,” the abstract states.

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.