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Two RNAi-Related Patent Applications Published by the US Patent Office: Jul 9, 2004


Title: Compositions and Methods for Treating Trail-Resistant Cancer Cells. Number: 20040126791. Filed: Sept. 19, 2003. Lead Inventor: Harald Wajant, Ribopharma (Alnylam).

The invention, the patent application’s abstract states, “relates to a double-stranded ribonucleic acid for inhibiting the expression of a cellular FLICE-like inhibitory protein gene, comprising a complementary RNA strand [that] is substantially identical to at least a part of a cFLIP gene.”

The abstract adds that the invention also relates “to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for inhibiting the expression of a cFLIP gene in a cell, methods for improving the effectiveness of an apoptosis-inducing drug, and methods for treating cancer using the pharmaceutical composition.”

Title: Colon Carcinoma-Related Oligonucleotides and Methods of Use. Number: 20040127450. Filed: Jan. 12, 2004. Inventor: Ramaswamy Narayanan, Florida Atlantic University.

According to the patent application’s abstract, the invention relates to “synthetic oligonucleotides (antisense, ribozymes, siRNA, and triple helix molecules) useful in down-regulating expression of a colon carcinoma-related gene nucleic acid or protein in a cell; and treatment method using said oligonucleotides alone or in combination with chemotherapy or radiation therapy.”

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.