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Two New RNAi-Related Patent Applications Published By USPTO


Title: Short Interfering RNAs Having a Hairpin Structure Containing a Non-Nucleotide Loop. Number: 20040058886. Filed: Aug. 5, 2003. Inventor: Stephen Scaringe, Dharmacon.

According to the patent application’s abstract, the invention “provides a short interfering hairpin RNA having the structure X1-L-X2, wherein X1 and X2 are nucleotide sequences having sufficient complementarity to one anther to form a double-stranded stem hybrid and L is a loop region comprising a non-nucleotide linker molecule, wherein at least a portion of one of the nucleotide sequences located within the double-stranded stem is complementary to a sequence of said target RNA.”

Title: Method and Reagent for Inhibiting Hepatitis B Viral Replication. Number: 20040054156. Filed: Jan. 15, 2003. Lead Inventor: Kenneth Draper, Sirna Therapeutics.

The patent application’s abstract states that the invention “relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, inozymes, zinzymes, amberzymes, and G-cleaver ribozymes, which modulate the synthesis, expression and/or stability of an RNA encoding one or more protein components of Hepatitis B virus (HBV).” The abstract adds that “methods for their use alone or in combination with other therapies, such as … lamivudine and interferons are disclosed.”


The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.